Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Integrase of Human Immunodeficiency Virus Type 1 (HIV-1 Integrase)
- Target
- HIV-1 Integrase
- Molecular classification
- Enzyme
01
Overview
HIV-1 integrase is a 32 kDa viral enzyme essential for the replication cycle of HIV-1. It catalyzes the integration of viral DNA into the host cell genome, a critical step that allows persistent infection and efficient viral replication. Integrase mediates two main reactions: 3'-Processing, and Strand Transfer. Integrase inhibitors block strand transfer activity by binding near or at the catalytic site—preventing incorporation of viral DNA into host chromosomes.
- Other names
- HIV-1 INIntegrase
02
Mechanism of action
Inhibition of strand transfer
03
Biological functions
Viral DNA integration3'-ProcessingStrand Transfer
04
Disease associations
InfectionHIV/AIDS
05
Safety considerations
Drug resistanceAdverse drug reactions
06
Interacting drugs
Raltegravir
3 more in the full profile.
07
Biomarkers
Plasma HIV RNA levelsCD4+ T-cell counts
Beyond the preview
Go deeper on Integrase of Human Immunodeficiency Virus Type 1 (HIV-1 Integrase).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Integrase of Human Immunodeficiency Virus Type 1 (HIV-1 Integrase).