Integrator complex subunit 13 (INTS13)

Integrator complex subunit 13 (INTS13) is a nuclear protein that forms a functional module (together with INTS10 and INTS14) within the Integrator complex, which regulates the transcriptional output of RNA polymerase II by facilitating 3′-end maturation and premature transcription termination for non-coding RNAs[1][2][3][5]. INTS13’s C-terminus directly binds the Integrator cleavage module (INTS4–INTS9–INTS11), a process critical for snRNA processing and required for proper spermatogenesis and cell cycle progression[1][2]. Genetic variants in INTS13 disrupt this interaction, resulting in ciliopathy and broad transcriptional dysregulation[2]. Although central to nuclear RNA metabolism and gene regulation, INTS13 is not classified as a direct therapeutic target, but rather as an essential cellular regulatory protein. It is not a receptor, enzyme, ion channel, or primary drug target, but a regulatory component crucial for RNA processing and maintenance of gene expression fidelity[1][2][5]. Absence or mutation results in clear pathophysiology (sterility, ciliopathy, impaired cell differentiation)[1][2]. Interacting subunits include INTS10, INTS14, and the Integrator cleavage module (INTS4, INTS9, INTS11)[1][2][3]. Structural studies reveal unexpected homology to DNA repair proteins (Ku70–Ku80), and a preference for RNA hairpin binding[1][3].

Other names

AsunderASUNC12orf11GCT1FLJ10637NET48Mat89BbSPATA30Cell cycle regulator Mat89Bb homologGerm cell tumor 1Protein asunder homologSarcoma antigen NY-SAR-95Spermatogenesis associated 30