Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Integrator complex subunit 15 (INTS15)
- Target
- INTS15
- Molecular classification
- Nuclear protein complex subunit, Non-catalytic subunit of the Integrator complex, Scaffold/structural protein, Other (not an enzyme, receptor, channel, or transporter)
01
Overview
Integrator complex subunit 15 (INTS15) is a newly defined, non-catalytic structural component of the human Integrator complex, a large nuclear multiprotein assembly that regulates the function and processing of nascent RNA transcripts synthesized by RNA polymerase II. INTS15 interacts physically and functionally within the INTS10–INTS13–INTS14–INTS15 subcomplex, which is involved in modulating the structure and activity of Integrator. Its principal molecular roles include support for small nuclear RNA 3′ end processing, mRNA splicing, and the regulation of transcription termination, particularly during eye and brain development. Mutations or functional deficiencies in INTS15 lead to aberrant splicing and manifest as congenital ocular and neurodevelopmental disorders. There is currently no evidence for INTS15 functioning as a direct pharmacological target, and it acts primarily as a structural and regulatory component rather than an enzyme or receptor.
- Other names
- INTS15Chromosome 7 open reading frame 26 (C7orf26)
02
Biological functions
Regulation of RNA polymerase II-dependent transcription3′ end processing of small nuclear RNAs (snRNAs)Regulation of mRNA splicingDevelopmental regulation (notably eye and brain development)Axonal outgrowth in neural cells
03
Disease associations
Ocular malformations/hereditary eye disease (genetic mutations cause autosomal dominant eye defects in humans and malformations in mice)Developmental abnormalities/neurodevelopmental disordersOther (possible but not directly implicated in common acquired human diseases or cancers as of current knowledge)
04
Safety considerations
Essential gene: Full knockout is embryonic lethal in mice, indicating that systemic inhibition would have severe developmental toxicity
Beyond the preview
Go deeper on Integrator complex subunit 15 (INTS15).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Integrator complex subunit 15 (INTS15).