Integrator complex subunit 6 (INTS6)

Integrator complex subunit 6 (INTS6) is a component of the multiprotein integrator complex involved in transcriptional regulation by RNA polymerase II, notably 3'-end processing of small nuclear RNAs (snRNAs) and regulatory termination of transcription, including non-coding RNAs such as enhancer RNAs, telomerase RNAs, and long non-coding RNAs[1][7]. INTS6 functions as a molecular adapter that aids in assembly of protein phosphatase 2A (PP2A) subunits to the core complex, facilitating transcription pause-release checkpoint control[1][7]. It is classified as a DEAD-box RNA helicase family member, featuring an Asp-Glu-Ala-Asp (DEAD) motif, with broad roles in gene expression regulation and nucleic acid metabolism[1][5][4]. Additionally, INTS6 promotes DNA repair by homologous recombination and is implicated in maintaining genome integrity[3]. INTS6 is context-dependent in cancer: it acts as a tumor suppressor in hepatocellular and prostate cancers by inhibiting cell proliferation and reducing Wnt/β‐catenin signaling, but may promote tumor growth in colorectal cancer via AKT and ERK pathway activation[3]. No drugs are currently reported to specifically target INTS6, either as inhibitors or activators, and there are no established mechanisms of action, established biomarkers, or safety concerns documented for INTS6-modulating therapies[1][3][5][7].

Other names

DBI1DDX26DDX26AInt6DICE1HDBNotchl2DBI-1protein deleted in cancer 1DEAD box proteinDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26RNA helicase HDB