Integrator complex subunit 7 (INTS7)

Integrator complex subunit 7 (INTS7) is a protein-coding gene that encodes a core component of the Integrator complex, which regulates RNA polymerase II–dependent transcription by mediating 3'-end processing of small nuclear RNAs such as U1 and U2 snRNAs. The Integrator complex forms a scaffold for both nuclease and phosphatase modules, and INTS7 is part of the backbone module together with INTS1 and INTS2. INTS7 is implicated in cellular responses to DNA damage where it participates in ATR signaling, and its expression is associated with disease aggressiveness in cancer types such as prostate and gastric cancer. It also modulates bone marrow mesenchymal stem cell differentiation and proliferation, indicating roles outside of classic RNA processing. INTS7 is not itself an enzyme, receptor, transporter, or current therapeutic target; it functions as an essential structural protein within a much larger multiprotein complex [1][2][3].

Other names

INTS7C1orf73INT7DKFZP434B168

Not applicable; INTS7 is not an established drug target. Its function is as part of a protein complex, not as a direct target of small molecules or biologics [1][3].