Integrator complex subunit 8 (INTS8)

Integrator complex subunit 8 (INTS8) is a protein encoded by the INTS8 gene and is a core component of the Integrator complex, which is essential for the 3′ end processing of small nuclear RNAs and transcriptional termination of RNA polymerase II transcripts. INTS8 acts as a multifunctional regulator of gene expression by recruiting protein phosphatase 2A (PP2A) to modulate transcriptional pause release and maintain transcriptional fidelity. Genetic alterations or dysregulation of INTS8 are implicated in neurodevelopmental disorders and several cancer types, where its overexpression is often linked to tumor progression, poor prognosis, and changes in the tumor microenvironment. Current studies highlight its emerging role as a diagnostic or therapeutic target, particularly in liver and gastrointestinal cancers.

Other names

INTS8C8orf52INT8NEDCHSprotein kaonashi-1FLJ20530MGC131633integrator complex subunit 8kaonashi-1

Not directly targeted by approved drugs; described as a potential therapeutic target in oncology via: Modulation of RNA processing and transcriptional regulation; Alteration of tumor-associated gene expression and immune environment; Association with mismatch repair genes and DNA methyltransferases in cancer