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Target intelligence / Profile preview
Integrin alpha-1 (CD49a)
- Target
- CD49a
- Molecular classification
- Integrin, Cell adhesion molecule, Receptor
01
Overview
CD49a, also known as Integrin alpha-1, is a cell surface receptor that forms a heterodimer with the beta 1 integrin subunit. This α1β1 integrin complex mediates cell adhesion to extracellular matrix proteins like collagen and laminin. It is expressed on various cell types, including immune cells and structural cells, and plays a role in cell migration, tissue repair, and immune responses. CD49a is involved in immune surveillance within tissues by resident memory lymphocytes. It is considered a therapeutic target for inflammation, infection and cancer.
- Other names
- VLA-1 (Very Late Antigen 1 α subunit)Laminin and Collagen Receptor
02
Mechanism of action
Blocking CD49a interaction with collagen/laminin, inhibiting cell adhesion and migration.
03
Biological functions
Cell adhesionCell migrationImmune responseTissue repairExtracellular matrix interaction
04
Disease associations
InflammationInfectionCancer (potentially involved in tumor microenvironment and metastasis)Fibrosis (tissue remodeling)Autoimmune diseases
05
Safety considerations
Potential for off-target effects due to broad expression on various cell typesRisk of disrupting normal tissue repair processes if completely blockedPotential for immune-related adverse events when modulating T cell function
06
Biomarkers
CD49a expression levels in tissue-resident memory T cells as a predictor of antiviral responseCD49a expression as a marker for specific T cell subsets in inflammatory diseases
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