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Integrin alpha 10 beta 1
- Molecular classification
- Receptor, Integrin, Cell adhesion molecule
01
Overview
Integrin alpha 10 beta 1 is a heterodimeric cell surface receptor composed of the integrin alpha-10 (ITGA10) and integrin beta-1 (ITGB1) subunits. It functions primarily as a collagen receptor, with a particularly important role in cartilage and skeletal development. It binds to collagen types II and IX. It is a marker for chondrocytes and potentially a therapeutic target in musculoskeletal research or cancer migration.
- Other names
- ITGA10/ITGB1Integrin subunit alpha 10PRO827
02
Mechanism of action
Not applicable directly, but modulation of integrin activation state (e.g., via divalent cation manipulation or inside-out signaling disruption) could theoretically impact its function.
03
Biological functions
Cell adhesionCell-matrix interactionChondrogenesisCell migrationSkeletal development
04
Disease associations
Skeletal disordersCancer (melanoma migration)Cartilage degradation
05
Safety considerations
Potential impact on bone growth if targeted inappropriatelyOff-target effects on other integrin-mediated processes
06
Biomarkers
Chondrocyte differentiation marker
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