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Target intelligence / Profile preview
Integrin alpha 2 (CD49b)
- Target
- CD49b
- Molecular classification
- Integrin, Receptor
01
Overview
Integrin alpha 2 (CD49b) is an integral membrane glycoprotein that forms heterodimers exclusively with the beta 1 subunit, resulting in the α2β1 integrin receptor. This receptor plays a crucial role in cell adhesion, particularly to collagens, and participates in cell-surface-mediated signaling. It is implicated in various disease contexts including cancer, infection and fibrosis.
- Other names
- CD49bITGA2
02
Biological functions
Cell-matrix adhesionSignal transductionTissue repairPlatelet adhesion
03
Disease associations
Cancer progressionImmune evasionViral infectionFibrosis
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