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Target intelligence / Profile preview
Integrin Alpha 2 Subunit (ITGA2)
- Target
- ITGA2
- Molecular classification
- Integrin, Transmembrane receptor
01
Overview
Integrin alpha-2 (CD49b) is a protein encoded by the ITGA2 gene in humans. It forms part of the integrin α2β1 heterodimeric receptor, also known as VLA-2, which is a member of the integrin superfamily—transmembrane receptors that mediate cell adhesion to extracellular matrix components and participate in signal transduction. It mediates platelet adhesion to multiple types of collagen—important for platelet aggregation during hemostasis and is involved in cell motility, angiogenesis, and stemness regulation. Also plays roles in immune regulation, and implicated in immune escape mechanisms.
- Other names
- CD49bVLA-2 alpha subunit
02
Mechanism of action
Adhesion blockade; Integrin antagonism
03
Biological functions
Cell adhesionSignal transductionPlatelet aggregationCell motilityAngiogenesisImmune regulation
04
Disease associations
CancerPlatelet-related disordersImmune evasionVascular diseasesDiabetes complications
05
Safety considerations
Potential for off-target effects due to broad expression.Potential disruption of hemostasis if platelet function is significantly inhibited.
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