Integrin alpha-3 (ITGA3)

Integrin alpha-3 is a transmembrane receptor protein encoded by the ITGA3 gene, functioning as the alpha subunit of the α3β1 integrin heterodimer. This receptor binds to extracellular matrix proteins, including laminin, fibronectin, and collagen, and mediates adhesion, migration, and signal transduction in epithelial, neural, and other cell types. Integrin alpha-3 plays critical roles in embryonic development, especially neural migration and corticogenesis, and is implicated in processes such as cell invasion (cancer metastasis), tissue integrity, and immune cell function. Dysregulation or mutation of ITGA3 is associated with diseases such as cancer, nephrotic syndrome, and autoimmune inflammation

Other names

Integrin alpha-3 heavy chainIntegrin alpha-3 light chainMSK18CD49cGAPB3VLA3aVCA-2GAP-B3CD49 antigen-like family member CFRP-2Galactoprotein B3VLA-3 subunit alphaalpha 3 subunit of VLA-3 receptorantigen CD49Cvery late activation receptor subunit alpha-3antigen identified by monoclonal antibody J143testicular tissue protein Li 96testicular tissue protein Li 98

Drugs or antibodies targeting integrin alpha-3 typically act by inhibiting binding of the integrin to its extracellular matrix ligands (e.g., laminins, fibronectin, collagen), thereby blocking cell adhesion, migration, and invasion processes relevant in cancer and inflammation