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Target intelligence / Profile preview
Integrin alpha 3 beta 1 (α3β1)
- Target
- α3β1
- Molecular classification
- Receptor, Integrin
01
Overview
Integrin alpha 3 beta 1 (α3β1) is a heterodimeric transmembrane receptor composed of the integrin alpha-3 (ITGA3) and beta-1 (ITGB1) subunits. It functions primarily as a cell surface adhesion molecule, mediating interactions between cells and the extracellular matrix (ECM). The α3β1 integrin is widely expressed in various tissues and plays critical roles in development, tissue organization, cell migration, and tumor progression.
- Other names
- VLA-3VCA-2ECMR1GAPB3
02
Biological functions
Cell adhesionCell migrationExtracellular matrix organizationImmune responseMatrix assembly
03
Disease associations
CancerInfectionTumor progressionMetastasis
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