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Target intelligence / Profile preview
Integrin alpha-4 (CD49d)
- Target
- CD49d
- Molecular classification
- Integrin, Receptor, Cell adhesion molecule
01
Overview
Integrin alpha-4 (ITGA4), also known as CD49d, is a member of the integrin alpha chain family. It forms heterodimers with either beta 1 (α4β1/VLA-4) or beta 7 (α4β7) and plays key roles in cell adhesion and migration by mediating interactions between cells and extracellular matrix proteins. It is involved in immune cell trafficking and is a therapeutic target for inflammatory diseases.
- Other names
- ITGA4CD49dα4 integrin
02
Mechanism of action
Integrin α₄ antagonists block the interaction of integrin α₄ with its ligands (VCAM-1, MADCAM-1, fibronectin), thereby inhibiting cell adhesion and migration.
03
Biological functions
Cell adhesionCell migrationImmune response regulationLeukocyte homingAxonogenesisRegulation of vascular endothelial cell proliferation/apoptosisCellular response to amyloid-beta peptide
04
Disease associations
InflammationUlcerative colitisImmune disorders
05
Safety considerations
Impaired immune surveillance
06
Interacting drugs
Carotegrast methyl
1 more in the full profile.
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