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Target intelligence / Profile preview
Integrin alpha-4 beta-1 (VLA-4)
- Target
- VLA-4
- Molecular classification
- Integrin, Cell Surface Receptor, Adhesion Receptor
01
Overview
Integrin alpha-4 beta-1 (VLA-4) is a heterodimeric cell surface receptor composed of alpha 4 (CD49d) and beta 1 (CD29) subunits. It mediates leukocyte trafficking, adhesion to endothelium via VCAM-1 and fibronectin, and plays a crucial role in inflammation, immune responses, and cancer metastasis. It is a therapeutic target for autoimmune and inflammatory diseases, notably targeted by natalizumab in multiple sclerosis.
- Other names
- VLA-4CD49d/CD29
02
Mechanism of action
Blocks α₄β₁ activity, inhibiting leukocyte adhesion and migration
03
Biological functions
Cell adhesionCell migrationSignal transductionImmune regulationLeukocyte traffickingHematopoietic stem/progenitor cell retention
04
Disease associations
Multiple sclerosis (MS)AsthmaSarcoidosisAllergic conjunctivitisCancer metastasisAutoimmune DisordersCNS Inflammation
05
Safety considerations
Progressive multifocal leukoencephalopathy (PML) risk with natalizumab
06
Interacting drugs
Natalizumab
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