Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Integrin alpha-4 beta-7 heterodimer (α4β7)
- Target
- α4β7
- Molecular classification
- Integrin, Cell Surface Receptor
01
Overview
Integrin α4β7 is a heterodimeric cell surface receptor that plays a critical role in immune cell trafficking, particularly in directing lymphocytes to gut-associated lymphoid tissues. It is composed of alpha-4 (CD49d; gene: ITGA4) and beta-7 (gene: ITGB7) subunits. α4β7 mediates adhesion and migration of lymphocytes by binding to specific ligands like MAdCAM-1, VCAM-1 and fibronectin, promoting homing of T and B lymphocytes to intestinal mucosa.
- Other names
- Lymphocyte Peyer’s patch adhesion molecule-1LPAM-1LPAM–1
02
Mechanism of action
Adhesion and migration of lymphocytes by binding to MAdCAM-1, VCAM-1, and fibronectin.
03
Biological functions
Cell adhesionCell migrationLymphocyte homingImmune cell traffickingInteraction with extracellular matrixTissue infiltrationImmune response
04
Disease associations
Inflammatory bowel diseaseInflammation
Beyond the preview
Go deeper on Integrin alpha-4 beta-7 heterodimer (α4β7).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Integrin alpha-4 beta-7 heterodimer (α4β7).