Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Integrin Alpha 5 Beta 1 (α5β1)
- Target
- α5β1
- Molecular classification
- Receptor, Integrin, Cell adhesion molecule
01
Overview
Integrin alpha 5 beta 1 (α5β1), also known as the fibronectin receptor, is a heterodimeric cell surface receptor composed of two subunits: α5 (ITGA5/CD49e) and β1 (ITGB1/CD29). It mediates cell-extracellular matrix (ECM) adhesion and plays critical roles in cellular signaling, migration, proliferation, survival, and differentiation. It primarily binds fibronectin via the RGD motif and is implicated in cancer metastasis, angiogenesis, and wound healing. It functions by triggering downstream signalling cascades involving kinases, leading to cytoskeletal reorganisation.
- Other names
- Fibronectin receptorITGA5/ITGB1CD49e/CD29
02
Mechanism of action
Inhibition of α5β1 binding to fibronectin, disruption of focal adhesion signaling, modulation of downstream kinase activity (e.g., FAK/Src), interference with actin cytoskeleton reorganization
03
Biological functions
Cell adhesionCell migrationFocal adhesion formationAngiogenesisCell signalingECM interaction
04
Disease associations
Cancer progressionCancer metastasisWound healingTissue repair
05
Safety considerations
Potential for off-target effects due to integrin family homologyRisk of disrupting normal cell adhesion and tissue homeostasisPotential for immune-related adverse events
06
Biomarkers
α5β1 expression levels in tumor tissueα5β1 expression levels in tumor vasculatureSoluble α5β1 levels in serum
Beyond the preview
Go deeper on Integrin Alpha 5 Beta 1 (α5β1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Integrin Alpha 5 Beta 1 (α5β1).