Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Integrin alpha-6 (ITGA6)
- Target
- ITGA6
- Molecular classification
- Integrin, Transmembrane glycoprotein, Receptor
01
Overview
Integrin alpha-6 (ITGA6) is a transmembrane glycoprotein that forms heterodimers with either the beta 1 (ITGB1) or beta 4 (ITGB4) subunits to create alpha6beta1 or alpha6beta4 integrins, both receptors for laminins. ITGA6 plays a critical structural role in hemidesmosomes of epithelial cells, anchoring epithelial layers to underlying tissue. It participates in cell adhesion, cell migration, and signal transduction affecting gene expression and cellular behavior. Mutations or dysregulation of ITGA6 are associated with genetic diseases like Junctional Epidermolysis Bullosa with Pyloric Atresia and cancer.
- Other names
- CD49fVLA-6ITGA6B
02
Biological functions
Cell adhesionCell migrationSignal transductionECM-receptor interactionFocal adhesion formationRegulation of actin cytoskeleton dynamicsHemidesmosome structure
03
Disease associations
Junctional Epidermolysis Bullosa with Pyloric AtresiaColitisAdenocarcinomaCancer
04
Safety considerations
Overexpression or altered function implicated in tumorigenesis
Beyond the preview
Go deeper on Integrin alpha-6 (ITGA6).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Integrin alpha-6 (ITGA6).