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Target intelligence / Profile preview
Integrin alpha-7 beta-1 (α7β1)
- Target
- α7β1
- Molecular classification
- Integrin, Transmembrane receptor
01
Overview
Integrin α7β1 is a heterodimeric transmembrane receptor composed of the alpha-7 (ITGA7) and beta-1 (ITGB1) subunits. It functions as a major laminin-binding integrin, primarily expressed in skeletal, cardiac, and smooth muscle tissues. This integrin plays critical roles in cell-matrix interactions, muscle development, regeneration, and maintenance of tissue integrity. Loss or mutation leads to muscular dystrophy phenotypes. Enhanced expression can compensate for loss of dystrophin-mediated linkage as seen in Duchenne muscular dystrophy.
- Other names
- Integrin α7β1ITGA7/ITGB1 heterodimer
02
Mechanism of action
N/A
03
Biological functions
Cell adhesionCell-matrix interactionMyoblast migrationMyoblast proliferationNeuromuscular junction formationMyotendinous junction formationMuscle fiber integrityVascular development
04
Disease associations
Muscular dystrophyCongenital myopathyVascular pathologies
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