Target intelligence / Profile preview

Integrin alpha FG-GAP repeat containing 1 (ITFG1)

Target: ITFG1
Molecular classification: Other (protein containing FG-GAP repeats), Possibly a cell-surface modulator (not a classical integrin or receptor)

Overview

Integrin alpha FG-GAP repeat containing 1 (ITFG1), also known as T-cell immunomodulatory protein (TIP), is a human protein coded by the ITFG1 gene. It contains FG-GAP repeats—domains seen in proteins involved with molecular/cellular interactions—and is thought to modulate T-cell immune function. ITFG1 has a reported protective effect in graft-versus-host disease models and is associated with diseases such as graft-versus-host disease and podoconiosis. There is evidence implicating ITFG1 in the collective invasion and progression of breast cancer cells through its interaction with RUVBL1. While its exact molecular mechanism and druggability are not fully defined, it is considered a potential immunomodulatory target based on experimental evidence[1][3][6].

Other names: T-cell immunomodulatory protein (TIP)ITFG1

Mechanism of action

Immune modulation/immune suppression (protective effect in graft-versus-host disease models)

Biological functions

Modulation of T-cell functionImmune regulationPossible involvement in cell collective invasion (breast cancer)

Disease associations

Graft-versus-host diseasePodoconiosisCancer (breast cancer invasion/progression)

Beyond the preview

Go deeper on Integrin alpha FG-GAP repeat containing 1 (ITFG1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Integrin alpha FG-GAP repeat containing 1 (ITFG1).

Explore the full profile