Integrin alpha FG-GAP repeat containing 2 (ITFG2)

Integrin alpha FG-GAP repeat containing 2 (ITFG2) is a highly conserved intracellular protein with two FG-GAP domains, which mediate critical protein-protein interactions involved in diverse cellular processes[1][4]. ITFG2 serves as a subunit of the KICSTOR complex, and is a regulator of the amino acid-sensing branch of the mTORC1 signaling pathway; it recruits the GATOR1 complex to lysosomal membranes and allows its interaction with other mTOR regulatory factors, thereby negatively regulating mTORC1 activity in the absence of amino acids or glucose[3][5][8]. ITFG2 also plays key roles in the differentiation and maturation of B cells, immune response modulation, and maintenance of immunoglobulin levels, with additional implications in the development of autoimmune diseases

Other names

ITFG2FGGAP1 (previous HGNC symbol)Integrin-α FG-GAP repeat-containing protein 22700050P07Rik (mouse)

No specific drug mechanism of action targeting ITFG2 is reported; its regulatory role in mTOR pathway suggests that inhibitors or activators of mTOR pathway might indirectly affect ITFG2 function