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Target intelligence / Profile preview
Integrin alpha-IIb (αIIb)
- Target
- αIIb
- Molecular classification
- Integrin, Receptor
01
Overview
Integrin alpha-IIb (αIIb or CD41) is a protein that combines with the beta-3 subunit to form the αIIbβ3 complex, a major receptor on platelets. It plays a critical role in hemostasis and thrombosis by mediating platelet aggregation through interactions with ligands like fibrinogen. Mutations in ITGA2B cause Glanzmann thrombasthenia. Antagonists targeting αIIbβ3 are used as antithrombotic agents.
- Other names
- CD41GPIIbintegrin subunit alpha 2bITGA2BBDPLT16GT
02
Mechanism of action
Antagonism of αIIbβ3 interaction with ligands like fibrinogen, preventing platelet aggregation
03
Biological functions
Cell adhesionPlatelet aggregationSignal transductionHemostasisThrombosis
04
Disease associations
Glanzmann thrombastheniaCardiovascular disease
05
Safety considerations
BleedingAdverse outcomes with oral antagonists in trials
06
Interacting drugs
Antithrombotic agents (αIIbβ3 antagonists)
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