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Target intelligence / Profile preview
Integrin alpha-IIb beta3 (GPIIb/IIIa)
- Target
- GPIIb/IIIa
- Molecular classification
- Integrin, Transmembrane receptor
01
Overview
Integrin alpha-IIb beta3 (GPIIb/IIIa) is a heterodimeric transmembrane receptor complex found predominantly on the surface of platelets and megakaryocytes. It plays a central role in platelet aggregation, hemostasis, and thrombosis. In its resting state, it does not bind ligands; upon platelet activation, it undergoes conformational changes that increase its affinity for soluble ligands such as fibrinogen and von Willebrand factor. Ligand binding leads to integrin clustering and outside-in signaling, which triggers further platelet activation processes. GPIIb/IIIa is targeted by several antiplatelet drugs used primarily during percutaneous coronary interventions.
- Other names
- CD41/CD61ITGA2B/ITGB3
02
Mechanism of action
Blocks ligand binding to GPIIb/IIIa to prevent pathological thrombosis
03
Biological functions
Platelet aggregationHemostasisThrombosisCell adhesionCell-matrix interactionsFibrinolysisCoagulation
04
Disease associations
Glanzmann thrombastheniaMyocardial infarctionStrokeArterial thrombosis
05
Safety considerations
Increased bleeding risk
06
Interacting drugs
Abciximab
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