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Target intelligence / Profile preview
Integrin alpha-L (CD11a)
- Target
- CD11a
- Molecular classification
- Integrin, Type I transmembrane glycoprotein, Cell surface receptor
01
Overview
Integrin alpha-L (CD11a, ITGAL) is a transmembrane glycoprotein that forms a heterodimer with integrin beta-2 (CD18) to create the LFA-1 complex. LFA-1 is expressed on all leukocytes and mediates cell-cell adhesion by binding to ICAMs on endothelial and immune cells. This interaction is crucial for leukocyte trafficking, immune cell activation, and cell-mediated cytotoxicity. Targeting CD11a can modulate immune responses, but it carries the risk of significant immunosuppression.
- Other names
- ITGALLeukocyte function-associated antigen 1 alpha chainLeukocyte adhesion glycoprotein LFA-1 alpha chainLFA-1AAntigen CD11A (p180)
02
Mechanism of action
Blocks the interaction of LFA-1 with ICAM-1, inhibiting T-cell activation and adhesion to endothelial cells.
03
Biological functions
Immune cell adhesionLeukocyte traffickingLymphocyte costimulatory signalingLymphopoiesisPhagocytosisCell-mediated cytotoxicity
04
Disease associations
InflammationAutoimmune diseasesCancer (metastasis)Immunodeficiency
05
Safety considerations
Progressive multifocal leukoencephalopathy (PML)Opportunistic infectionsImmunosuppression
06
Interacting drugs
Efalizumab
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