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Target intelligence / Profile preview
Integrin alpha M subunit (CD11b)
- Target
- CD11b
- Molecular classification
- Integrin, Type I transmembrane glycoprotein, Receptor
01
Overview
CD11b antigen is an essential component of innate immunity—serving both structural roles (adhesion/migration) and regulatory functions that modulate inflammation. Its broad expression among myeloid-derived immune cells makes it invaluable both clinically—as a diagnostic/prognostic tool—and experimentally—as an indicator of innate immune activity across tissues. It forms a heterodimer with CD18 to form the Mac-1 integrin. Mac-1 binds ligands such as iC3b, fibrinogen and factor X to mediate cell adhesion and phagocytosis. CD11b also plays a role in immune regulation.
- Other names
- ITGAMMacrophage-1 antigen (Mac-1)Complement receptor 3 alpha (CR3A)C3bi receptor (C3biR)Mo-1
02
Biological functions
Cell adhesionCell migrationPhagocytosisImmune regulationLeukocyte recruitmentToll-like receptor signaling modulationB-cell receptor signaling suppressionT-cell activation suppressionDendritic cell maturation/function suppressionOsteoclast differentiationBone remodelingOxidative burst modulationApoptosis modulation
03
Disease associations
Inflammatory diseasesAutoimmune disordersAcute Myeloid Leukemia (AML)Neuroinflammation
04
Safety considerations
Potential for off-target effects due to broad myeloid expressionAltered expression/function in autoimmune disorders or malignanciesMicroglia identification in neuroscience research is not specific
05
Biomarkers
Myeloid lineage cell identificationAML diagnosis/prognosis
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