Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Integrin alpha-V (ITGAV)
- Target
- ITGAV
- Molecular classification
- Receptor, Cell surface receptor protein, Integrin
01
Overview
Integrin alpha-V (ITGAV) is a cell surface receptor protein that plays a central role in cell adhesion, migration, and signal transduction by interacting with various extracellular matrix (ECM) proteins and other ligands. It forms heterodimeric complexes with different beta subunits, leading to distinct integrin receptors with varying ligand specificities. Alpha V integrins mediate cell adhesion to ECM components, influence cell survival/migration/proliferation, activate TGF-beta, and act as viral entry receptors. Altered expression is implicated in diseases like visceral myopathy, West Nile Virus susceptibility, and cancer.
- Other names
- CD51Vitronectin receptor alpha polypeptideIntegrin alpha-V heavy chain/light chain
02
Biological functions
Cell adhesionCell migrationSignal transductionActivation of latent transforming growth factor-beta (TGF-beta)Coreceptor functions for cytokinesViral entry receptor
03
Disease associations
Visceral myopathy type 1Susceptibility to West Nile Virus infectionCancer progression/metastasis
Beyond the preview
Go deeper on Integrin alpha-V (ITGAV).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Integrin alpha-V (ITGAV).