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Target intelligence / Profile preview
Integrin alpha-V beta-1 (αVβ1)
- Target
- αVβ1
- Molecular classification
- Integrin, Transmembrane receptor, Cell adhesion molecule
01
Overview
Integrin alpha-V beta-1 (αVβ1) is a heterodimeric transmembrane receptor that mediates cell adhesion and signaling between cells and the extracellular matrix. It is composed of alpha-V (ITGAV) and beta-1 (ITGB1) subunits. αVβ1 recognizes ligands containing the RGD motif, including vitronectin, fibronectin, and osteopontin. It plays key roles in cell adhesion, migration, signal transduction, embryogenesis, tissue repair, and angiogenesis. Compared to other fibronectin receptors, αVβ1 binds fibronectin with lower affinity, facilitating dynamic attachment/detachment during cell migration. It serves as an entry receptor for some viruses and is involved in tumor progression/metastasis.
- Other names
- Integrin αVβ1alphaVbeta1 integrinVitronectin receptor (partial)CD51/CD29ITGAV/ITGB1
02
Mechanism of action
RGD motif binding; Modulation of cell adhesion and signaling
03
Biological functions
Cell adhesionCell migrationSignal transductionExtracellular matrix interactionAngiogenesisVirus entry
04
Disease associations
CancerAngiogenesis-related diseasesInfectionWound healing
05
Safety considerations
Potential for off-target effects due to broad ligand specificityModulation of angiogenesis can have both beneficial and detrimental effects depending on the context
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