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Target intelligence / Profile preview
Integrin alpha V beta 3 (αVβ3)
- Target
- αVβ3
- Molecular classification
- Integrin, Cell surface receptor
01
Overview
Integrin alpha V beta 3 (αVβ3) is a heterodimeric cell surface receptor that mediates cell adhesion, migration, and signal transduction. It is composed of alpha V (CD51) and beta 3 (CD61) subunits and binds to extracellular matrix proteins containing the RGD motif. It is highly expressed on endothelial cells, osteoclasts, platelets, and some immune cells. αVβ3 plays a critical role in angiogenesis, tumor metastasis, bone resorption, and hemostasis, making it a therapeutic target for cancer, bone diseases, and other conditions.
- Other names
- alphaVbeta3αVβ3 integrinCD51/CD61Vitronectin receptor
02
Mechanism of action
Inhibition of integrin αVβ3 binding to ligands, induction of apoptosis
03
Biological functions
Cell adhesionCell migrationSignal transductionMechanotransductionAngiogenesisBone resorptionHemostasisPhagocytosis
04
Disease associations
Cancer progression/metastasisAngiogenesisBone diseasesAutoimmune disordersInflammatory disorders
05
Interacting drugs
Etaracizumab
4 more in the full profile.
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