Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Integrin alpha-V beta-5 (αVβ5)
- Target
- αVβ5
- Molecular classification
- Integrin, Receptor, Transmembrane protein
01
Overview
Integrin alpha-V beta-5 (αVβ5) is a heterodimeric transmembrane receptor composed of alpha V (ITGAV) and beta 5 (ITGB5) subunits. It binds to ligands containing an RGD (Arg-Gly-Asp) motif, notably vitronectin. αVβ5 mediates cell adhesion, migration, and signal transduction and plays roles in retinal pigment epithelium function, cancer, and viral infection. It is located primarily on the plasma membrane.
- Other names
- CD51/CD49eVNRAVTNRIntegrin αVβ5Alpha-V Beta-5 Integrin
02
Mechanism of action
RGD sequence recognition and binding to extracellular matrix proteins; Integrin activation and downstream signaling.
03
Biological functions
Cell adhesionCell migrationSignal transductionPhagocytosisExtracellular matrix interactionViral entry
04
Disease associations
CancerInfectionEye disease (e.g., Retinitis Pigmentosa)Wound healing
05
Safety considerations
Potential for off-target effects due to RGD sequence promiscuity.Modulation of angiogenesis could have unintended consequences.
Beyond the preview
Go deeper on Integrin alpha-V beta-5 (αVβ5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Integrin alpha-V beta-5 (αVβ5).