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Integrin alpha V beta 6 (αvβ6)
- Target
- αvβ6
- Molecular classification
- Integrin, Cell surface receptor
01
Overview
Integrin αvβ6 is a heterodimeric cell surface receptor composed of the αv (CD51) and β6 subunits. It mediates cell adhesion to the extracellular matrix (ECM) and plays key roles in signal transduction, cellular migration, proliferation, and differentiation. It is minimally expressed in healthy adult tissues but highly upregulated during pathological processes such as cancer and fibrosis, making it a potential therapeutic target. It uniquely activates latent TGF‑β1.
- Other names
- alpha v beta 6 integrinαvβ6 integrinCD51/CD104ITGAV/ITGB6 heterodimer
02
Mechanism of action
Antibodies or small molecules that block ligand binding or internalization pathways
03
Biological functions
Cell adhesionActivation of TGF-β1Regulation of immune surveillanceSignal transductionCell migrationCell proliferation
04
Disease associations
CancerFibrosisWound healingInflammationViral infection
05
Safety considerations
Potential for off-target effects due to RGD motif recognition by other integrinsDisruption of normal TGF-β signaling
06
Biomarkers
Expression level in tumor tissue
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