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Target intelligence / Profile preview
Integrin alpha V beta 8 (αvβ8)
- Target
- αvβ8
- Molecular classification
- Integrin, Cell Surface Receptor, Transmembrane protein
01
Overview
Integrin alpha V beta 8 (αvβ8) is a heterodimeric cell surface receptor composed of the αV (ITGAV) and β8 (ITGB8) subunits. It is a unique integrin that plays a key role in activating latent transforming growth factor beta (TGF-beta), influencing processes such as immune regulation, tissue remodeling, fibrosis, tumor progression, angiogenesis, and neurodevelopmental events. Unlike most integrins, αvβ8 remains constitutively active and activates TGF-beta through a protease-dependent mechanism.
- Other names
- Integrin αvβ8alpha V beta 8 integrinITGAV/ITGB8CD51/CD298
02
Mechanism of action
Modulation of TGF-beta signaling, disruption of cell adhesion
03
Biological functions
Cell adhesionCell-cell communicationTGF-beta activationExtracellular matrix interactionImmune regulationTissue remodelingAngiogenesisNeurodevelopment
04
Disease associations
FibrosisTumor progressionCancerNeurodevelopmental disordersInflammation
05
Safety considerations
Potential for off-target effects due to RGD motif recognitionDisruption of TGF-beta signaling pathways may lead to unintended consequencesEffects on angiogenesis and tumor microenvironment need careful consideration
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