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Target intelligence / Profile preview
Integrin alpha-V beta1 (αVβ1)
- Target
- αVβ1
- Molecular classification
- Integrin, Receptor, Transmembrane protein
01
Overview
Integrin alpha-V beta1 (αVβ1) is a heterodimeric transmembrane receptor composed of the integrin alpha V (ITGAV) and integrin beta 1 (ITGB1) subunits. It mediates cell adhesion to the extracellular matrix (ECM), playing roles in cellular signaling, migration, and tissue organization. It primarily binds ECM proteins containing the RGD motif, including vitronectin, fibronectin, and osteopontin. While it functions as a fibronectin receptor, it does not support robust fibronectin matrix assembly or efficient cell migration on fibronectin compared to α5β1. αVβ1 is involved in processes such as angiogenesis, wound healing, tissue repair, embryogenesis, immune response modulation, and potentially tumor metastasis.
- Other names
- ITGAV/ITGB1Integrin alphaVbeta1CD51/CD29
02
Mechanism of action
Integrin antagonists block ligand binding and downstream signaling.
03
Biological functions
Cell adhesionCell migrationExtracellular matrix interactionSignal transductionAngiogenesis regulationWound healingTissue repairEmbryogenesisImmune response modulation
04
Disease associations
CancerTumor progressionMetastasisAngiogenesis
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