Integrin alpha-V beta3 (αVβ3)

Integrin αVβ3 is a heterodimeric cell surface receptor composed of αV and β3 subunits. It mediates cell adhesion to the extracellular matrix via RGD motifs, primarily found in vitronectin, fibronectin, fibrinogen, laminin, thrombospondin, vWF, osteopontin and tenascin. It plays a critical role in angiogenesis, bone resorption, and cell signaling, and is implicated in cancer, cardiovascular disorders, and autoimmune diseases. It is a target for antiangiogenic therapies.

Other names

Integrin αVβ3alphaVbeta3 integrinVitronectin receptor

αVβ3 antagonists inhibit angiogenesis by blocking the interaction of αVβ3 with ECM proteins and growth factors, leading to reduced endothelial cell proliferation, migration, and survival. Some antagonists, like ProAgio, induce apoptosis by recruiting caspase 8 to the receptor.