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Target intelligence / Profile preview
Integrin alpha-V beta5 (αVβ5)
- Target
- αVβ5
- Molecular classification
- Receptor, Integrin, Type I transmembrane glycoprotein
01
Overview
Integrin αVβ5 is a heterodimeric cell surface receptor composed of integrin alpha V (ITGAV) and integrin beta 5 (ITGB5) subunits. It mediates cell adhesion to vitronectin via the RGD motif and participates in endocytosis, signal transduction, and angiogenesis. It is expressed on various cell types and is considered a potential therapeutic target in diseases involving abnormal angiogenesis or tumor progression.
02
Mechanism of action
RGD motif binding inhibitors
03
Biological functions
Cell adhesionEndocytosisSignal transductionAngiogenesisCell migration
04
Disease associations
CancerAbnormal angiogenesisTumor progression
05
Safety considerations
Potential for off-target effects due to RGD motif promiscuityAngiogenesis modulation may have complex and context-dependent effects
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