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Integrin alpha-V beta6 (αvβ6)
- Target
- αvβ6
- Molecular classification
- Integrin, Cell Surface Receptor
01
Overview
Integrin alpha-V beta6 (αvβ6) is a heterodimeric cell surface receptor composed of the αv (CD51) and β6 subunits. It mediates cell-cell and cell-extracellular matrix interactions and is primarily expressed on epithelial cells, with upregulation during tissue remodeling, wound healing, fibrosis, inflammation, and cancer. Its main function is activation of transforming growth factor-beta 1 (TGF-β1), regulating cell proliferation, differentiation, angiogenesis, EMT, and immune suppression. It binds to fibronectin, tenascin C, and the latency-associated peptide (LAP) of TGF-beta. Due to its restricted expression and involvement in disease, it's a promising therapeutic target in cancer and fibrotic diseases.
- Other names
- Integrin αvβ6CD51/CD104alpha-V beta6 integrin
02
Mechanism of action
Inhibition of integrin binding to ligands, disruption of TGF-β activation
03
Biological functions
Cell adhesionCell-extracellular matrix interactionTGF-β activationWound healingEpithelial-mesenchymal transition (EMT)Immune modulationViral entry
04
Disease associations
CancerFibrosisInflammation
05
Safety considerations
Potential for off-target effects due to interactions with other integrinsImmunogenicity of inhibitory antibodies or peptides
06
Biomarkers
Expression levels in tumor tissueExpression levels in fibrotic tissue
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