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Target intelligence / Profile preview
Integrin Alpha V Subunit (ITGAV)
- Target
- ITGAV
- Molecular classification
- Integrin alpha chain family, Receptor
01
Overview
Integrin alpha V, encoded by the ITGAV gene in humans, is a subunit of integrins—heterodimeric integral membrane proteins composed of an alpha and a beta subunit. These proteins are essential for cell surface adhesion to the extracellular matrix (ECM) and play key roles in signal transduction. Alpha V can pair with several beta chains (Beta 1, Beta 3, Beta 5, Beta 6, Beta 8), forming distinct integrin receptors with unique ligand specificities. It mediates cell adhesion to ECM components and signal transduction influencing cell proliferation, survival, and migration. Dysregulation is associated with diseases including viral infection susceptibility and cancer.
- Other names
- Integrin alpha-VVitronectin receptor alpha subunitCD51VNRA
02
Mechanism of action
Alpha V-containing integrins mediate cell adhesion to ECM components and signal transduction influencing cell proliferation, survival, and migration.
03
Biological functions
Cell adhesionSignal transductionCell proliferationCell survivalCell migrationAngiogenesisWound healingEmbryo implantation
04
Disease associations
CancerWest Nile Virus infection susceptibilityHerpes Simplex virus infection susceptibilityPathological angiogenesis
05
Safety considerations
Potential for off-target effects due to broad expression and multiple dimerization partners.
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