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Target intelligence / Profile preview
Integrin alpha2beta1 (VLA-2)
- Target
- VLA-2
- Molecular classification
- Integrin, Receptor
01
Overview
Integrin alpha2beta1, also known as VLA-2, is a heterodimeric transmembrane receptor composed of the α2 (CD49b) and β1 (CD29) subunits. It functions primarily as a collagen receptor, mediating cell adhesion to various types of collagen in the extracellular matrix. It plays a role in cell migration, costimulation of T cells, and resistance to apoptosis. It is implicated in autoimmune diseases, inflammation, and tumor metastasis.
- Other names
- CD49b/CD29ITGA2/ITGB1
02
Mechanism of action
Not applicable, target of drug resistance.
03
Biological functions
Cell adhesionCell-matrix adhesionCostimulationSurvival signalingLeukocyte traffickingImmune responseCell migration
04
Disease associations
Autoimmune diseasesRheumatoid arthritisInflammationTumor metastasis
05
Safety considerations
Potential for immunosuppressionOff-target effects on other integrin-mediated processes
06
Interacting drugs
Methotrexate
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