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Integrin alpha4 (CD49d)
- Target
- CD49d
- Molecular classification
- Integrin, Cell adhesion molecule, Receptor
01
Overview
Integrin alpha4, also known as CD49d, is a transmembrane protein that functions as an integrin alpha subunit. It forms heterodimers with either the beta1 (CD29) or beta7 integrin subunits to create functional receptors on the cell surface. The most notable complexes are: α4β1 (VLA-4) and α4β7 (LPAM-1). Integrins containing the alpha 4 subunit play critical roles in cell adhesion, cell-cell adhesion, and trafficking of hematopoietic cells. Antagonists targeting integrin alpha 4 have been developed for inflammatory diseases such as ulcerative colitis.
- Other names
- CD49 antigen-like family member DCD49DIntegrin alpha-4Lymphocyte Peyer patch adhesion molecules subunit alphaITGA4
02
Mechanism of action
Antagonist targeting integrin alpha 4
03
Biological functions
Cell adhesion mediated by integrinsCell-cell adhesionTrafficking of hematopoietic cellsImmune responseAxonogenesis involved in innervationNeuron projection extensionClathrin-dependent exosome endocytosisRegulation of vascular endothelial cell proliferation/apoptosisCellular responses to amyloid-beta
04
Disease associations
InflammationMultiple sclerosisCrohn's diseaseUlcerative colitis
05
Interacting drugs
Carotegrast methyl
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