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Target intelligence / Profile preview
Integrin Alpha4 Beta1 (VLA-4)
- Target
- VLA-4
- Molecular classification
- Integrin, Cell adhesion receptor
01
Overview
Integrin alpha4 beta1, also known as Very Late Antigen-4 (VLA-4), is a heterodimeric cell surface receptor that plays crucial roles in cell adhesion and signaling processes. It is composed of alpha4 and beta1 subunits and is expressed on various immune cells. VLA-4 mediates leukocyte migration, promotes inflammation, and participates in cell-cell and cell-extracellular matrix interactions. It is implicated in inflammatory diseases and autoimmune conditions, making it a therapeutic target for controlling these disease processes.
- Other names
- Very Late Antigen-4alpha4 beta1 integrinCD49d/CD29
02
Mechanism of action
Inhibition of VLA-4 binding to VCAM-1
03
Biological functions
Cell adhesionLeukocyte migrationSignal transductionImmune cell regulationCo-stimulation
04
Disease associations
Inflammatory diseasesAutoimmune conditions
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