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Target intelligence / Profile preview
Integrin alpha4 beta7 (α4β7)
- Target
- α4β7
- Molecular classification
- Integrin, Cell surface receptor
01
Overview
Integrin alpha4 beta7 (α4β7), also known as LPAM-1, is a heterodimeric cell surface receptor that plays a crucial role in lymphocyte homing to gut-associated lymphoid tissue. It is composed of alpha 4 (CD49d) and beta 7 subunits. The primary ligand for α4β7 is MAdCAM-1, expressed on endothelial cells of the gut. α4β7 is a therapeutic target for inflammatory bowel diseases, and antibodies against it are used clinically to block lymphocyte trafficking to the gut.
- Other names
- LPAM-1Lymphocyte Peyer’s patch adhesion molecule-1CD49d/CD29ITGA4/ITGB7
02
Mechanism of action
Antibody-mediated blockade of α4β7 interaction with MAdCAM-1, preventing lymphocyte trafficking to the gut.
03
Biological functions
Cell adhesionLymphocyte homingImmune cell traffickingT cell activationB cell activationRegulatory T cell function
04
Disease associations
Inflammatory bowel diseaseHIV infection
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