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Integrin alpha4-containing complexes
- Molecular classification
- Receptor, Integrin
01
Overview
Integrin alpha4-containing complexes are cell surface receptors formed by the pairing of the integrin alpha4 subunit (CD49d) with either a beta1 or beta7 subunit, resulting in α4β1 (VLA-4) and α4β7. These complexes mediate leukocyte adhesion to vascular endothelium via VCAM-1 during inflammation and facilitate lymphocyte homing to specific tissues such as gut mucosa through interaction with MAdCAM-1. They are therapeutic targets for autoimmune diseases.
- Other names
- α4β1 (VLA-4)α4β7CD49d complexes
02
Mechanism of action
Antagonists block recruitment/retention of leukocytes at sites of inflammation; agonists may promote release/detachment under certain conditions
03
Biological functions
Cell adhesionCell migrationLeukocyte homingImmune cell traffickingInflammatory response
04
Disease associations
Autoimmune diseasesMultiple sclerosisUlcerative colitisInflammation
05
Interacting drugs
Natalizumab
1 more in the full profile.
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