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Target intelligence / Profile preview
Integrin alpha5 beta1 (α5β1)
- Target
- α5β1
- Molecular classification
- Integrin, Cell Surface Receptor
01
Overview
Integrin α5β1, also known as the fibronectin receptor, is a heterodimeric transmembrane protein that mediates cell adhesion to the extracellular matrix (ECM). It plays a crucial role in cell migration, signaling, and cytoskeletal organization. Its interaction with fibronectin is essential for various biological processes, including development, wound healing, and cancer progression. Overexpression of integrin α5β1 is associated with poor prognosis in several cancers, making it a potential therapeutic target for anti-cancer drug development.
- Other names
- CD49e/CD29Fibronectin receptor
02
Mechanism of action
Antagonists targeting α5β1 inhibit its interaction with fibronectin, disrupting cell adhesion, migration, and downstream signaling pathways.
03
Biological functions
Cell adhesionCell migrationSignal transductionCytoskeletal organizationWound healingTissue morphogenesis
04
Disease associations
Cancer progressionMetastasisAngiogenesisTumor development
05
Safety considerations
Potential for off-target effects due to RGD sequence recognition by other integrins.Possible disruption of normal cell adhesion and migration processes.
06
Biomarkers
Expression level of α5β1 in tumor tissue
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