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Target intelligence / Profile preview
Integrin alpha5beta1 (ITGA5:ITGB1)
- Target
- ITGA5:ITGB1
- Molecular classification
- Receptor, Integrin
01
Overview
Integrin alpha5beta1 is a major cellular receptor for fibronectin, playing a crucial role in cell adhesion, migration, and signaling. It mediates bidirectional signaling across the cell membrane, influencing cell behavior and fate. Overexpression of integrin alpha5beta1 is associated with aggressive cancer types, making it a therapeutic target for cancer treatment.
- Other names
- Fibronectin receptor
02
Mechanism of action
Integrin alpha5beta1 inhibitors block the interaction between the integrin and its ligands, such as fibronectin, thereby disrupting cell adhesion, migration, and signaling pathways involved in tumor growth and metastasis.
03
Biological functions
Cell adhesionCell migrationSignal transductionECM assembly
04
Disease associations
CancerTumor progressionMetastasis
05
Safety considerations
Potential for off-target effects due to RGD sequence promiscuityPossible disruption of normal cell adhesion and tissue homeostasis
06
Biomarkers
Integrin alpha5beta1 expression levels in tumor tissueSoluble fibronectin levels
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