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Target intelligence / Profile preview
Integrin alpha9 (ITGA9)
- Target
- ITGA9
- Molecular classification
- Integrin, Type I transmembrane glycoprotein, Receptor
01
Overview
Integrin alpha9 (ITGA9) is a type I transmembrane glycoprotein and a member of the integrin family. It forms a heterodimer with the beta1 subunit (α9β1) and mediates cell-cell and cell-matrix adhesion. It interacts with ligands such as Tenascin-C and VCAM1 and plays roles in inflammation, cancer progression, vascular diseases, and axon regeneration, making it a potential therapeutic target.
- Other names
- ITGA4LALPHA-RLC
02
Mechanism of action
Modulation of cell adhesion and downstream signaling pathways (e.g., FAK activation)
03
Biological functions
Cell adhesionCell migrationLymphocyte egress regulationLymphatic valve formationPhenotype switching in vascular smooth muscle cellsTumor progression/metastasisAxon damage repair/regenerationThrombosis regulation
04
Disease associations
InflammationRheumatoid arthritisCancerSmall cell lung cancerVascular diseasesAcute aortic dissection
05
Safety considerations
Potential for off-target effects due to integrin family promiscuityImpact on normal tissue homeostasis during therapeutic intervention
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