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Integrin alphaEbeta7 (αEβ7)
- Target
- αEβ7
- Molecular classification
- Integrin, Cell Surface Receptor
01
Overview
Integrin alphaEbeta7 (αEβ7) is a heterodimeric cell surface receptor belonging to the integrin family. It is composed of alpha E (CD103, encoded by ITGAE) and beta 7 (encoded by ITGB7) subunits. This integrin is primarily expressed on T lymphocytes, especially those residing in mucosal tissues. It facilitates retention of T lymphocytes within epithelial layers through binding to E-cadherin, maintaining immune surveillance. αEβ7 expression is often increased during inflammatory conditions. Monoclonal antibodies targeting β7 or blocking αEβ7-E-cadherin interactions are under investigation for treating diseases like IBD.
- Other names
- CD103/ITGAE + ITGB7
02
Mechanism of action
Disrupting trafficking into and retention within the inflamed gut tissue by blocking integrin-ligand interaction.
03
Biological functions
Cell adhesionImmune regulationLymphocyte retention at epitheliaImmune surveillance
04
Disease associations
Inflammatory bowel diseaseOther conditions with mucosal inflammation
05
Interacting drugs
Humanized monoclonal antibodies targeting β7
1 more in the full profile.
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