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Target intelligence / Profile preview
Integrin alphaV (ITGAV)
- Target
- ITGAV
- Molecular classification
- Integrin, Integral membrane glycoprotein, Receptor
01
Overview
Integrin alphaV, encoded by the ITGAV gene, is a key member of the integrin family, which are heterodimeric transmembrane receptors involved in cell adhesion, migration, and signal transduction. It pairs with several beta subunits (β1, β3, β5, β6, and β8) to form distinct receptors with different tissue distributions and ligand specificities. AlphaV-containing integrins mediate cell adhesion to ECM components and regulate angiogenesis, tumor invasion/metastasis, and other biological processes. They recognize ligands containing an RGD (Arg-Gly-Asp) motif and are targets for anti-cancer therapies aimed at inhibiting tumor growth or metastasis.
- Other names
- alphaV integrin subunitCD51Vitronectin receptor alpha subunit
02
Mechanism of action
Inhibition of integrin-mediated cell adhesion and signaling
03
Biological functions
Cell adhesionCell migrationSignal transductionAngiogenesisWound healingECM binding
04
Disease associations
CancerTumor invasion/metastasisAngiogenesis-related diseasesFibrosis
05
Safety considerations
Potential for off-target effects due to broad expression of alphaV-containing integrinsAngiogenesis inhibition may impair normal wound healing
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