Target intelligence / Profile preview

Integrin alphaVbeta5 (αvβ5)

Target: αvβ5
Molecular classification: Integrin, Cell Surface Receptor

Overview

Integrin αvβ5 is a heterodimeric cell surface receptor composed of alpha V (ITGAV) and beta 5 (ITGB5) subunits. It mediates cell adhesion, migration, and signal transduction through interactions with the extracellular matrix (ECM), particularly with ligands containing an RGD motif like vitronectin and fibronectin. αvβ5 plays a key role in processes such as cell attachment, proliferation, and survival, and also serves as a receptor/co-receptor for viral entry, including adenovirus and adeno-associated virus type 2 (AAV2).

Biological functions

Cell adhesionCell migrationSignal transductionCell proliferationWound healing

Disease associations

Viral infectionCancer (potential role in angiogenesis, though not explicitly stated in text provided)Other (Implicit role in diseases where cell adhesion/migration/ECM interaction is important)

Safety considerations

Potential impact on gene therapy via AAV vectors

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