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Target intelligence / Profile preview
Integrin alphaVbeta6 (αvβ6)
- Target
- αvβ6
- Molecular classification
- Receptor, Integrin
01
Overview
Integrin αvβ6 is a heterodimeric cell surface receptor composed of the αv and β6 subunits. It mediates cell-to-extracellular matrix (ECM) and cell-to-cell adhesion and signal transduction. Its principal function is the activation of latent TGF-β1, influencing cell proliferation, differentiation, angiogenesis, EMT, and immune suppression. It is upregulated in various cancers and fibrotic conditions, making it an attractive therapeutic target.
02
Mechanism of action
Antibody-drug conjugates or inhibitors to block αvβ6-mediated TGF‑β activation and downstream signaling pathways.
03
Biological functions
Cell adhesionCell-to-extracellular matrix adhesionTGF-β activationCell proliferationDifferentiationAngiogenesisEpithelial-mesenchymal transition (EMT)Immune suppressionWound healingTissue remodeling
04
Disease associations
CancerFibrosisWound HealingInflammationGenetic Disorders (amelogenesis imperfecta & periodontal disease)
05
Safety considerations
Potential off-target effects due to integrin family promiscuity.Possible disruption of normal wound healing processes.
06
Biomarkers
αvβ6 expression levels in tumor tissue
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