Target intelligence / Profile preview

Integrin alphaVbeta8 (αvβ8)

Target: αvβ8
Molecular classification: Integrin, Receptor, Transmembrane receptor

Overview

Integrin alphaVbeta8 (αvβ8) is a heterodimeric transmembrane receptor composed of the αv (ITGAV) and β8 (ITGB8) subunits. It belongs to the αv integrin subfamily. Unlike most other integrins, β8 is unique in both structure and function. It primarily binds latent TGF-beta complexes, activating TGF-beta signaling. αvβ8 is expressed in various tissues and plays a role in cell-cell interactions, neurodevelopment, fibrosis and cancer. Antagonists are being developed to block pathological TGF-beta activation in diseases such as cancer.

Other names: alphaVbeta8 integrinITGAV/ITGB8 heterodimer

Mechanism of action

Antagonists targeting αvβ8 block pathological TGF-beta activation.

Biological functions

Cell-cell communicationTGF-beta activationECM binding

Disease associations

NeurodegenerationFibrosisCancer progressionImmunosuppression

Safety considerations

Potential for broad TGF-beta pathway modulation leading to unforeseen consequences.Off-target effects due to RGD-motif binding promiscuity to other integrins.

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