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Integrin beta 1 subunit (ITGB1)
- Target
- ITGB1
- Molecular classification
- Receptor, Integrin
01
Overview
Integrin beta-1 (ITGB1) is a single-chain type I glycoprotein and a member of the integrin family of cell surface receptors. It forms heterodimers with various alpha subunits, resulting in multiple distinct integrins that mediate cell-cell and cell-extracellular matrix (ECM) interactions. These complexes are essential for processes such as embryogenesis, tissue repair, immune response, hemostasis, and cancer metastasis.
- Other names
- CD29ITB1
02
Mechanism of action
N/A
03
Biological functions
Cell adhesionCell migrationCell-ECM interactionSignal transductionEmbryogenesisTissue repairImmune responseHemostasis
04
Disease associations
CancerEmbryonic development defectsDefective wound healingTissue repair
05
Safety considerations
Complex roles make therapeutic targeting challenging.Potential for off-target effects due to broad expression.
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