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Target intelligence / Profile preview
Integrin Beta 2 (CD18)
- Target
- CD18
- Molecular classification
- Integrin, Transmembrane protein
01
Overview
Integrin beta 2 (CD18) is a transmembrane protein that serves as the common beta chain for all β2 integrins. It plays a crucial role in leukocyte adhesion, migration, and immune response. Deficiency or dysfunction leads to impaired immune responses such as Leukocyte Adhesion Deficiency type I. Targeting specific interactions involving β₂-integrins has therapeutic potential for modulating inflammatory diseases or sepsis without broadly suppressing immunity.
- Other names
- ITGB2ITGb2ITG-B2LADLFA1MAC1LCAMBMF17
02
Mechanism of action
Modulating interactions with ICAMs and other ligands
03
Biological functions
Cell adhesionCell migrationLeukocyte adhesionImmune responsePhagocytosisSignal transduction
04
Disease associations
Leukocyte Adhesion Deficiency Type IInflammationSepsisImmunodeficiency
05
Safety considerations
Potential for immunosuppression if broadly targetedRisk of infection if immune cell migration is excessively inhibited
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